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Google Scholar 8. Google Scholar PubMed Article Google Scholar Google Scholar Download references. Acknowledgements The author is grateful to D. Supplementary information PDF files 1. Rights and permissions To obtain permission to re-use content from this article visit RightsLink. About this article Publication history Published 28 August Further reading Using human experience to identify drug repurposing opportunities: theory and practice D.

Druzhilovskiy , A. Rudik , D. Filimonov , T.

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Dubovskaya , S. Ivanov , O. Tarasova , V. Bezhentsev , K. Murtazalieva , M.

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Changing R&D models in research-based pharmaceutical companies

Semin , I. Maiorov , A. Gaur , G. Mantel-Teeuwisse , Diederick S. Schutjens Drug Discovery Today Article Tools.

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Kamalakar has over 16 year experience in the field of computer aided drug design. NovaLead explores generic drugs to find new indication possibilities in these areas. Such candidates have little chance of failure on account of safety as their safety profile in humans is well documented through historic use for their original indication. Thus eliminating one of the major causes of late stage drug failures. NovaLead's' pipeline has several candidates at different stages of development. The lead compounds in NovaLead's pipeline are given below:. Psoriasis candidate is application of an FDA approved generic drug molecule.

World over, more than million people have Diabetes, expected to rise to million in DFU is a leading cause of lower extremety amputation. Every 20 seconds somewhere in the world, a lower limb is amputated due to DFU. DFU remains a serious disease with very limited drug options and very high cost of treatment. NovaLead team has discovered novel anti-inflammatory activity for an FDA approved generic drug molecule having potential for inflammatory skin diseases like psoriasis and dermatitis. A series of experimental validations by in vitro studies also confirmed the activity of the candidate for psoriasis.

The candidate NLP91 is under further pre-clinical validations in animal models. It is the most prevalent autoimmune disease in the U.

Modern Strategy for Preclinical Pharmaceutical R&D

The disease negatively impacts quality of life for majority of patients. Many biologics approved for arthritis are in use for treating severe posiriasis. Due to limitations of these drugs, there is a dire need for an effective and longer lasting treatment for mild-to-moderate psoriasis. Psoriasis affects about million people worldwide As of , annual medical costs for psoriasis are estimated at USD 3.

It includes methods for flexible receptor-drug docking interaction analysis, molecular shape based similarity identification, molecular fragments to activity relationship studies and active site structure analysis to name a few. Besides this, it employs extensive drug-disease-target knowledgebase which is acompendium of databases of FDA approved drugs, validated drug targets, mechanism of actions for various diseases and the intelligent correlations between these datasets.

The platform set up consists of modern multi-core parallel processing cluster which churns millions of molecular simulations to deliver an all inclusive interaction analysis. NovaLead's' RVHTS technology can be effectively employed for product life cycle management and reviving shelved compounds. It also assists in identifying most appropriate disease for an early stage molecule. NovaLead team either starts with the intended drug molecule or preferred protein target or the disease of interest.


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If this interests you, please visit us on www. NovaLead believes in the spirit of partnership and collaboration. We are open to explore partnering as well as licensing alternatives. We expect our drug candidates to follow the b 2 route for FDA filing and similar regulatory paths for EU, Japan and other regulated markets. Beside the product candidates in our pipeline, we are also open for customer-driven collaboration.

We can help you find novel indications of existing drugs, using our proprietary discovery platform. The award was received by our CEO Mr. Supreet Deshpande in presence of distinguished business and industry leaders in a glittering function held on 05 Oct at ITC Maratha, Mumbai.

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The team consists of chemists, biochemists, pharmacologists and technicians, all with long experience and strong expertise in ADME-studies. Admescope serves customers in 25 different countries on four continents, having planned and conducted a high number of ADME-related studies to biotech and big pharma companies. Our business strengths rely on high technical expertise and top-notch research facilities, combined with attractive strategic partnerships and academic collaborations. The company's full product offerings range from general molecular modeling programs to a comprehensive suite of drug design software, as well as a state-of-the-art suite for materials research.

The methodology is to combine screening tests using one or more organisms that mimic effects in humans. Vivaltes technology has been proven to be highly predictive and therefore of high value in the lead finding process.

In addition, using data-driven science, species-specific databases are mined and combined in a single knowledge framework to facilitate data analytics. Cross-species data comparison allows further selection of compounds of interest, reducing cost and shortening time to market. We make science talk! Culture takes years to build and we know how important this is to find and retain the right people. Ncardia is a stem cell drug discovery and development company operating worldwide with facilities and offices in Belgium, the Netherlands, Germany and the USA.

The company is privately held and has been established following the merger of Pluriomics and Axiogenesis. Our goal is to be the supportive and trusted partner for scientists operating in the hiPSC drug discovery and development space including cardiovascular and neural safety and efficacy studies. Hyve is a young, innovative, and fast-growing IT company.